The Rolex Registry (Revascularization Of LEft Main With Resolute onyX)

Inclusion Criteria: * Subject \> 18 years old * ULMCAD with angiographic diameter stenosis \>50% (if 50-70% evidence of FFR \<0.80 or IVUS minimal lumen area \<6.0 mm2 is recommended. * Silent ischemia, stable angina, unstable angina or non-ST elevation myocardial infarction * Ability to provide written informed consent and comply with follow-up for at least 2 years. Exclusion Criteria: 1. Clinical exclusion criteria: * Prior PCI on the left main trunk or prior CABG. * Concomitant indication to cardiac surgery (severe heart valve disease etc.) * Cardiogenic Shock (Killip\>2) * Severe renal insufficiency (GFR \<30 ml/min) * Known impaired left ventricular function (left ventricular ejection fraction \<30%) * Inability to tolerate or comply with dual antiplatelet therapy for at least 1 year * Pregnancy or intention to become pregnant * Life expectancy less than 1 year * Other investigational drug or device studies that have not reached their primary endpoint 2. Angiographic exclusion criteria: * Left main diameter stenosis \<50% * SYNTAX score \>33