Open and Exploratory Trial to Investigate the Pharmacokinetic of Ceftobiprole Medocaril in Patients With CSF Device

Inclusion Criteria: * Adult patients (\> 18 years) * Provision of informed consent prior to any study specific procedures * Female patients of childbearing potential may be entered if pregnancy testing is negative and the patient agrees to abstain from procreational sexual intercourse or must use double-barrier contraceptive measures for the duration of the study * Presence of an indwelling external CSF access device (ventriculostomy or lumbar drain) * Presence of inflamed meninges as a result of documented or suspected meningitis or ventriculitis. Patients with both clinical symptoms (fever, headache, meningismus, and altered mentation) and laboratory parameters (CSF leukocytosis, defined as a CSF white blood cell count \[WBC\] of \>103, elevated CSF protein, defined as CSF protein of \>1g/l, reduced CSF glucose, defined as CSF glucose of \<0.3g/l, or a positive CSF Gram stain or culture) indicative of CNS infection were deemed to have definitive bacterial meningitis/ventriculitis. Inflamed meninges were defined as the presence of \>5 leukocytes/mm3 of CSF. * Person with antibacterial treatment (including treatment for the current meningitis or ventriculitis) * Glycemia above 3 mmol/l and below 10 mmol/l * Natremia below 145 mmol/l * Capnia below 45 mmHg * No other patient included within 72 hours from D0 (treatment period) of the previous patient * Agreement of the scientific committee Exclusion Criteria: * Hypersensitivity to MABELIO® (ceftobiprole) or to one of its excipient or another 3rd cephalosporin * Hypersensitivity to cephalosporin * Immediate and severe hypersensitivity to β-lactam antimicrobial other than Mabelio and other cephalosporins * Pregnant or breast feeding women * Renal insufficiency defined as creatinine clearance \< 50 mL/min * Patient with creatinine clearance \> 150 mL/min * Patients with conditions known or suspected to alter pharmacokinetics (i.e., burn or cystic fibrosis patients) * Refusal to participate * Person not affiliated to the social security * Absolute necessity of immediate removing the device