Evaluation of TRC101 in Subjects With Metabolic Acidosis Associated With Chronic Kidney Disease

Key Inclusion Criteria: * Blood bicarbonate level of 12 to 20 mEq/L. * Estimated glomerular filtration rate (eGFR) of 20 to 40 mL/min/1.73m2. * Stable kidney function defined as \<=20% variability in eGFR during screening period. Key Exclusion Criteria: * Any level of low blood bicarbonate during the screening period that in the opinion of the Investigator, requires emergency intervention or evaluation for an acute acidotic process. * Anuria, dialysis, acute kidney injury, or history of acute kidney insufficiency within 3 months prior to screening. * Heart failure with maximum New York Heart Association (NYHA) Class IV symptoms or that required hospitalization during the preceding 6 months. * Heart or kidney transplant. * Chronic obstructive pulmonary disease (COPD) that is treated with chronic oral steroids, that requires the subject to be on oxygen, or that required hospitalization within the previous 6 months. * Change in doses to alkali therapy in the 4 weeks prior to screening. * History or current diagnosis of diabetic gastroparesis, bowel obstruction, swallowing disorders, inflammatory bowel disease, major gastrointestinal surgery, frequent diarrhea or active gastric/duodenal ulcers. * Serum calcium \<= 8.0 mg/dL at screening. * Planned initiation of renal replacement therapy within 12 weeks following randomization. * Use of polymeric binder drugs within 14 days prior to screening.