Regulation of Metabolism and Ion Handling

Morten Hostrup, PhD30 enrolled

Overview

This study investigates the relation between ion-handling (K+) and fatigue development during exercise. Before and after a 6-week period of high intensity interval training, performance and ion-handling is assessed in young adults. In addition, mitochondrial function is examined.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

Speed endurance trainingBEHAVIORAL

Speed endurance training

Eligibility

Sex: MALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy men * 45-55 ml/kg/min * BMI 19-26 kg/m2 * Normal ECG (assessed by MD) Exclusion Criteria: * Allergic to n-acetylcystine (NAC) or digoxin * Severe side effects from NAC or digoxin * Chronic diseases (assessed by MD to be a potential hazard or to interfere with outcome measures)

Locations (1)

University of Copenhagen

Copenhagen, Denmark

Outcomes

Primary Outcomes

Quadriceps endurance

Time to exhaustion during knee-extensor exercise

Time frame: Change from before (baseline) to after 6 weeks of training (Week 6)

Secondary Outcomes

K+ release

Net leg K+ release in mmol/min during knee-extensor exercise

Time frame: Change from before (baseline) to after 6 weeks of training (Week 6)

Data from ClinicalTrials.gov

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