Genotype, Metabotype and Diet in a Cohort of Children and Adolescents From the Southeast of Spain.

National Research Council, Spain423 enrolled

Overview

The objective of this study is to investigate the possible association between 60 SNPs related to obesity, metabolism and cardiovascular disease with BMI, intestinal microbiota and adherence to the Mediterranean diet in a cohort of children and adolescents from the southeast of Spain.

The objective of this study is to investigate the possible association between 60 single nucleotide polymorphisms (SNPs) related to obesity, metabolism and cardiovascular disease with the body mass index (BMI), intestinal microbiota related to the metabolism of polyphehnos and adherence to the Mediterranean diet in a cohort of children and adolescents from the southeast of Spain. The volunteers (n=423) with ages ranging from 5 to 18 years consumed for three days a daily serving of walnuts (30g) and provided a sample of urine (to determine mirobial-derived metabolites from walnut polyphenols) as well as a swab specimen from the inner cheek to provide DNA for further genotyping.

Study Type

INTERVENTIONAL

Allocation

Purpose

SCREENING

Masking

NONE

Enrollment

423

Conditions

Genotype, Metabotype and Dietary Habits

Interventions

WalnutsOTHER

The group consumed a daily serving of walnuts (30 g) or 200 mL pomegranate juice for 3 days and provided a sample of urine as well as a swab specimen from the inner cheek

Pomegranate juiceOTHER

Those volunteers who were allergic to nuts consumed 200 mL pomegranate juice daily for 3 days and provided a sample of urine as well as a swab specimen from the inner cheek

Eligibility

Sex: ALLMin age: 5 YearsMax age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy individuals aged 5 to 18 years. * Informed consent signed by the parent / legal representative, and by volunteers who are already 18 years old. Exclusion Criteria: * Known or suspected allergy or intolerance to nuts or pomegranate. * Intake of antibiotics 1 month before the start of the study. * If the participant could perceive stress or psychological damage due to his participation. * Any other circumstance different from previous ones (illness, etc.), according to which it is considered that the intervention in the study may involve some type of affectation.

Locations (1)

Cebas-Csic

Murcia, Spain

Outcomes

Primary Outcomes

Polyphenol metabotypes

Type of ellagic acid-derived microbial metabolites in urine

Time frame: 1 to 3 months

Secondary Outcomes

Genotype

Detection of 60 SNPs related to obesity, metabolism and cardiovascular disease

Time frame: 1 to 6 months

Adherence to Mediterranean diet

Evaluation of the adherence to Mediterranean diet using validated questionnaires

Time frame: 1 to 3 months

Data from ClinicalTrials.gov

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