EMD for Treatment of Proximal Class-II Furcation Involvements

N/ACompletedNCT03320135

Universidade Estadual Paulista Júlio de Mesquita Filho34 enrolled

Overview

The aim of the present study is to evaluate the clinical response of proximal furcations treated with enamel matrix derivative proteins (EMD).

Proximal class-II furcation represents a challeng to periodontal therapy. Studies show that the ultrasonic non-surgical therapy doesn't work in these defects and the guided tissue regeneration therapy with membranes also demonstrates an unpredictable improvement. Therefore, enamel matrix derivative proteins (EMD) have been proposed as a periodontal regenerative procedure due to their fundamental role in cementum development.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Generalized Aggressive Periodontitis

Interventions

Enamel matrix derivative proteinsPROCEDURE

Open flap debridement to enamel matrix derivative to treat proximal furcation involvements.

Open Flap debridementPROCEDURE

Open flap debridement will be performed to decontaminate the proximal furcation involvements.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of generalized aggressive periodontitis (Armitage, 1999; American Academy of Periodontology, 2015); * Have undergone a first approach for periodontal treatment (full-mouth ultrasonic debridement); * Presence of one proximal class-II furcation presenting probing depth \> 4 mm and bleeding on probing ; * Good general health; * Agree to participate in the study and sign the informed consent form (TCLE) after explaining the risks and benefits; Exclusion Criteria: * Systemic problems (cardiovascular alterations, blood dyscrasias, immunodeficiency - ASA III / IV / V) that contraindicate the periodontal procedure; * Have used antibiotics and anti-inflammatories in the last six months; * Smoke ≥ 10 cigarettes/day; * Pregnant or lactating; * Chronic use of medications that may alter the response of periodontal tissues; * Indication of antibiotic prophylaxis for dental procedures;

Locations (1)

Naira Andere

São José dos Campos, São Paulo, Brazil

Outcomes

Primary Outcomes

Horizontal clinical attachment level

horizontal component of the defect

Time frame: 1 year

Data from ClinicalTrials.gov

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