Use of Prothrombin Complex Concentrate in Patients Admitted in Emergency Care Units for Severe Bleeding While Receiving Oral Anticoagulants

Inclusion Criteria: * Adult patients (≥ 18 years old) * Receiving oral anticoagulants (VKA or DOAC) * With a severe bleeding episode meeting at least one of the following criteria * External hemorrhage which cannot be controlled by usual means or * Hemodynamic instability: SBP \< 90 mmHg or SBP decrease * 40 mmHg from usual SBP or mean BP \< 65 mmHg or any sign of shock or * Patient requiring a hemostatic procedure in emergency: surgery, interventional radiology, endoscopy or * Need for transfusion of packed red blood cells or * Hemorrhage jeopardizing the vital or functional prognosis: e.g. intracranial hemorrhage, intraspinal hemorrhage, intraocular or retro-ocular hemorrhage, hemothorax, hemoperitoneum, retroperitoneal hemorrhage, hemopericardium, deep muscle hematoma or compartment syndrome, acute digestive hemorrhage, hemarthrosis. * Admitted in the participating emergency service * Accepting the collection of his/her own health-related data Exclusion Criteria: * Patient participating in another interventional study * Pregnant or nursing woman * Patient under supervision or legal guardianship