Impact of Neurological Diseases on the Prognosis of Bullous Pemphigoid: A Retrospective Study of 178 Patients

N/ACompletedNCT03320798

CHU de Reims178 enrolled

Overview

Bullous pemphigoid affects mainly elderly patients. It is often associated with neurologic disorders, which represent a major risk factor of the disease

The aim was to determine whether neurologic disorders, especially dementia, influences outcome and mortality of patients with bullous pemphigoid.

Study Type

OBSERVATIONAL

Enrollment

178

Conditions

Bullous Pemphigoid

Interventions

Data recordOTHER

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients presenting bullous pemphigoid using the following criteria: clinical features typical of BP with presence of at least three out of four well-established criteria of Vaillant et al., subepidermal blister on skin biopsy and deposits of IgG and/or C3 in a linear pattern along the epidermal basement membrane zone by direct IF * patients consulting at dermatology department of Reims Teaching Hospital (France) between 1997 and 2011

Locations (1)

Damien JOLLY

Reims, France

Outcomes

Primary Outcomes

neurological disease

neurological disease are dementia (Alzheimers disease or other dementia), Parkinson's syndrome and stroke. Diagnosis of dementia was carried out in several ways: after examination by a neurologist or geriatrician, when the Mini Mental State was less than or equal to 17 or in the presence of a demonstrated and clinically evident dementia.

Time frame: Day 0

Data from ClinicalTrials.gov

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