Adipokines of Epicardial Adipose Tissue and Atherosclerosis of Coronary Arteries

University Hospital, Ioannina160 enrolled

Overview

The aim of the study is to investigate whether the expression and production of adipokines secreted by the epicardial adipose tissue correlate with the degree of coronary atherosclerosis.

The aim of the study is to investigate whether the expression and production of four adipokines \[adiponectin, omenin-1, resistin and retinol binding protein-4 (RBP4)\] secreted by the epicardial adipose tissue correlate with the degree of coronary atherosclerosis. Specifically, this study aims to investigate whether the expression and production of these adipokines is different between two sites of the heart, that are perfused by coronary arteries with different degrees of stenosis.

Study Type

OBSERVATIONAL

Enrollment

160

Conditions

Coronary Atherosclerosis Adipokines

Eligibility

Sex: MALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1\) Individuals undergoing cardiac surgery Exclusion Criteria: * Age \< 18 years * HbA1c \> 7.0% * Any change of antidiabetic medication the previous 3 months before the surgery * GFR \< 60 mL/min/1.73 m2 * Liver disease * Cancer * Non-treated hyperthyroidism or hypothyroidism * Autoimmune disease * Infection * Any change in body weight at least 5% the previous 3 months before surgery * Significant dehydration. * Taking any of the following drugs the previous 3 months before surgery: hormones, antiobesity drugs

Locations (1)

University Hospital of Ioannina

Ioannina, Greece

RECRUITING

Outcomes

Primary Outcomes

Association between coronary artery disease and epicardial adipokines

Comparison of the mRNA and protein production of four adipokines \[adiponectin, omentin-1, resistin, retinol binding protein-4(RBP4)\] from the epicardial adipose tissue between the territories that are supplied by LAD and RCA. This comparison will be performed in the following clusters of groups: 1. Cluster 1: NonDM-0 and DM-0 (comparison between territories that are supplied by non-stenosed coronary arteries) 2. Cluster 2: NonDM-LR and DM-LR (comparison between territories that are supplied by stenosed coronary arteries) 3. Cluster 3: NonDM-L, NonDM-R, DM-L and DM-R (comparison between a territory that is supplied by stenosed coronary artery and another territory that is supplied by non-stenosed coronary artery)

Time frame: Baseline measurement

Secondary Outcomes

Impact of diabetes on epicardial adipokines

Comparison of the mRNA and protein production of four adipokines (adiponectin, omentin-1, resistin, RBP4) from the epicardial adipose tissue of the territory that is supplied by LAD or RCA between the following groups: 1. NonDM-0 vs DM-0 2. NonDM-L vs DM-L 3. NonDM-R vs DM-R 4. NonDM-LR vs DM-LR

Time frame: Baseline measurement

Central Contacts

Eustratios Apostolakis, Professor

CONTACT

0030 2651099679 stratisapostolakis@yahoo.gr

Data from ClinicalTrials.gov

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