ExAblate Blood Brain Barrier Disruption (BBBD) for Planned Surgery in Suspected Infiltrating Glioma

Inclusion Criteria: 1. Male or Female between 21-85 years of age 2. Able and willing to give informed consent 3. Subjects with suspected infiltrating glioma on pre-operative brain imaging scans including non-enhancing MRI tumor components in non-eloquent regions that are within the planned surgical resection volume 4. Surgical area targeted for ExAblate treatment (i.e. prescribed Region of Treatment) ≤30 cm3; planned surgical resection volume may exceed the targeted treatment volume 5. Karnofsky Performance Score 70-100 6. Able to communicate sensations during the ExAblate® BBBD procedure Exclusion Criteria: 1. MRI or clinical findings of: * Active or chronic infection(s) or inflammatory processes * Acute or chronic hemorrhages, specifically any lobar microbleeds, and no siderosis, amyloid angiopathy, or macrohemorrhages * Intracranial thrombosis, vascular malformation, cerebral aneurysm or vasculitis * Evidence of tumor-related calcification, cyst, or hemorrhage * Midline shift of \>10mm or evidence of subfalcine, uncal, or tonsillar herniation on pre-operative imaging 2. More than 30% of the skull area traversed by the sonication pathway is covered by scars, scalp disorders (e.g., eczema), or atrophy of the scalp 3. Clips, shunts, or any metallic implanted objects in the skull or the brain or the presence of unknown MR unsafe devices anywhere within the body 4. Significant cardiac disease or unstable hemodynamic status 5. Uncontrolled hypertension (systolic \> 150 and diastolic BP \> 100 on medication) 6. Receiving anticoagulant (e.g. warfarin) or antiplatelet (e.g. aspirin) therapy within one week of focused ultrasound procedure or drugs known to increase risk of hemorrhage (e.g. Avastin) within one month of focused ultrasound procedure 7. History of a liver disease, bleeding disorder, coagulopathy or a history of spontaneous hemorrhage 8. Abnormal coagulation profile (Platelets \< 100,000), PT (\>14) or PTT (\>36), and INR \> 1.3 9. Lacunar lesions or evidence of increased risk of bleeding 10. Known cerebral or systemic vasculopathy 11. Significant depression and at potential risk of suicide 12. Known sensitivity/allergy to gadolinium, or other intravascular contrast agents 13. Active seizures despite medication treatment (defined as \>1 seizure per month) which could be worsened by disruption of the blood brain barrier 14. Evidence of worsening neurological function 15. Dexamethasone dose ≥ 24mg daily or equivalent steroid dose 16. History of drug or alcohol disorder which have a higher risk for seizures, infection and/or poor executive functioning 17. Positive HIV status, which can lead to increased entry of HIV into the brain parenchyma leading to HIV encephalitis 18. Potential blood-borne infections which can lead to increased entry to brain parenchyma leading to meningitis or brain abscess 19. Any contraindications to MRI scanning, including: * Large subjects not fitting comfortably into the scanner * Difficulty lying supine and still for up to 3 hours in the MRI unit or claustrophobia 20. Untreated, uncontrolled sleep apnea 21. Impaired renal function with estimated glomerular filtration rate \<30 mL/min/1.73m2 22. Respiratory: chronic pulmonary disorders e.g. severe emphysema, pulmonary vasculitis, or other causes of reduced pulmonary vascular cross-sectional area, patients with a history of drug allergies, asthma or hay fever, and multiple allergies where the benefit/risk of administering Definity® is considered unfavorable by the study physicians in relation to the product labeling for Definity 23. Currently in a clinical trial involving an investigational product or non-approved use of a drug or device