Obinutuzumab in Marginal Zone Lymphoma

Inclusion Criteria: Patients must have a proven pathological diagnosis of MZL. Patients must meet all of the following inclusion criteria to be eligible for participation in this study: * Confirmed CD20 positive de novo MALT Lymphoma following or being not eligible for local therapy (including surgery, radiotherapy) and antibiotics for H. pylori-positive gastric lymphoma arisen at any extranodal site * Confirmed CD20 positive de novo splenic MZL following or not being eligible for local therapy (including surgery and antiviral therapy for Hepatitis C Virus) with symptomatic disease * Confirmed CD20 positive de novo nodal MZL * Patients in need of treatment: For patients with symptomatic splenic, nodal, or non-gastric extranodal MZL disease that is de novo or has relapsed following local therapy (i.e., surgery or radiotherapy) and requires therapy, as assessed by the investigator. For patients with symptomatic gastric extranodal MZL: Helicobacter pylori-negative disease that is de novo or has relapsed following local therapy (i.e., surgery or radiotherapy) and requires therapy, as assessed by the investigator, or H. pylori-positive disease that has remained stable, progressed, or relapsed following antibiotic therapy and requires therapy, as assessed by the investigator - At least one bi-dimensionally measurable lesion (\> 2 cm in its largest dimension by CT scan or MRI). In patients with splenic MZL, an enlarged spleen on CT scan or extending at least 2 cm below the costal margin by physical examination will constitute measurable disease providing that no explanation other than lymphomatous involvement is likely. For an enlarged liver to constitute the only measurable disease parameter, a liver biopsy showing proof of NHL in the liver is required. For SMZL: * Bulky progressive or painful splenomegaly * one of the following symptomatic/progressive cytopenias : Hb \< 10 g/dL, or Plat \< 80.000 /microL, or neutropenia \< 1000 /microL, whatever the reason (autoimmune or hypersplenism or bone marrow infiltration) * enlarged lymphoadenopathy or involvement of extranodal sites with or without cytopenia * splenectomised patients with rapidly raising lymphocyte counts, development of lymphadenopathy or involvement of extranodal sites * SMZL with concomitant hepatitis C infection who have not responded to or are relapsed after Interferon and/or Ribavirin (patients positive for HCV antibody are eligible only if PCR is negative for HCV RNA. For gastric MALT Lymphoma: \- H. pylori-negative cases following or being not eligible for local therapy (i.e., surgery, radiotherapy or antibiotics). Others: * Age greater than 18 years * Life expectancy \>3 months. * Baseline platelet Count 50, 109/L, if not due to BM Infiltration by the lymphoma, absolute neutrophil Count 0.75, 109/L * Meet the following pretreatment laboratory criteria at the Screening visit conducted within 28 days of study enrollment (unless due to underlying lymphoma): * ASAT (SGOT): 3 times the upper limit of institutional laboratory normal value * ALAT (SGPT): 3 times the upper limit of institutional laboratory normal value * Total Bilirubin: 20 mg/L or 2 times the upper limit of institutional laboratory normal value, unless clearly related to the disease (except if due to Gilbert's syndrome) * Serum creatininie \<= 2mg/dl * Pregnancy beta-HCG negative. For women of child-bearing potential only; serum or urine beta-HCG must be negative during screening and at study enrolment visit * Negative HIV antibody * Positive test results for chronic HBV infection (defined as positive HBsAg serology): patients with occult or prior HBV infection (defined as negative HBsAg and positive total HBcAb) may be included if HBV DNA is undetectable, provided that they are willing to undergo monthly DNA testing. Patients who have protective titers of HBSAb after vaccination or prior but cured hepatitis B are eligible. * Positive test results for hepatitis C (hepatitis C virus (HCV) antibody serology testing): patients positive for HCV antibody are eligible only if PCR is negative for HCV RNA. * Premenopausal fertile females must agree to use a highly effective method of birth control for the duration of the therapy up to 6 months after end of therapy. A highly effective method of birth control is defined as those which result in a low failure rate (i.e. less than 1% per year) when used consistently and correctly such as implants, injectables, combined oral contraceptives, some IUDs, sexual abstinence or vasectomised partner. * Men must agree not to father a child for the duration of therapy and 6 months after and must agree to advice a female partner to use a highly effective method of birth control. * Willingness and ability to comply with scheduled visits, drug administration plan, imaging studies, laboratory tests, other study procedures, and study restrictions. * Evidence of a personally signed informed consent indicating that the subject is aware of the neoplastic nature of the disease and has been informed of the procedures to be followed, the experimental nature of the therapy, alternatives, potential benefits, possible side effects, potential risks and discomforts, and other pertinent aspects of study participation. The presence of any of the following will exclude a subject from enrolment: * ECOG performance status \>2 * History of a non-lymphoid malignancy except for the following: adequately treated local basal cell or squamous cell carcinoma of the skin, cervical carcinoma in situ, superficial bladder cancer, asymptomatic prostate cancer without known metastatic disease and with no requirement for therapy or requiring only hormonal therapy and with normal prostate specific antigen for ≥1 year prior to study enrollment visit, other Stage 1 or 2 cancer treated with a curative intent and currently in complete remission, for ≥3 years. * Central nervous system lymphoma, leptomeningeal lymphoma, or histologic evidence of transformation to a high-grade or diffuse large B-cell lymphoma. * Ann Arbor Stage I disease * Ongoing immunosuppressive therapy other than corticosteroids * Evidence of ongoing systemic bacterial, fungal, or viral infection at the time of study enrollment visit * Ongoing drug-induced liver injury, chronic active hepatitis B (HBV), alcoholic liver disease, non-alcoholic steatohepatitis, primary biliary cirrhosis, extrahepatic obstruction caused by cholelithiasis, cirrhosis of the liver, or portal hypertension. * Ongoing alcohol or drug addiction * Treatment with any other investigational agent or participating in another trial within 30 days prior to entering this study * Breastfeeding or pregnancy * Prior or ongoing clinically significant illness, medical condition, surgical history, physical finding, electrocardiogram (ECG) finding, or laboratory abnormality that, in the investigator's opinion, could adversely affect the safety of the subject or impair the assessment of study results. * History of anaphylaxis in association with previous administration of monoclonal antibodies. * Vaccination with a live vaccine within 28 days prior to start of therapy Exclusion Criteria: The presence of any of the following will exclude a subject from enrolment: * ECOG performance status \>2 * History of a non-lymphoid malignancy except for the following: adequately treated local basal cell or squamous cell carcinoma of the skin, cervical carcinoma in situ, superficial bladder cancer, asymptomatic prostate cancer without known metastatic disease and with no requirement for therapy or requiring only hormonal therapy and with normal prostate specific antigen for ≥1 year prior to study enrollment visit, other Stage 1 or 2 cancer treated with a curative intent and currently in complete remission, for ≥3 years. * Central nervous system lymphoma, leptomeningeal lymphoma, or histologic evidence of transformation to a high-grade or diffuse large B-cell lymphoma. * Ann Arbor Stage I disease * Ongoing immunosuppressive therapy other than corticosteroids * Evidence of ongoing systemic bacterial, fungal, or viral infection at the time of study enrollment visit * Ongoing drug-induced liver injury, chronic active hepatitis B (HBV), alcoholic liver disease, non-alcoholic steatohepatitis, primary biliary cirrhosis, extrahepatic obstruction caused by cholelithiasis, cirrhosis of the liver, or portal hypertension. * Ongoing alcohol or drug addiction * Treatment with any other investigational agent or participating in another trial within 30 days prior to entering this study * Breastfeeding or pregnancy * Prior or ongoing clinically significant illness, medical condition, surgical history, physical finding, electrocardiogram (ECG) finding, or laboratory abnormality that, in the investigator's opinion, could adversely affect the safety of the subject or impair the assessment of study results. * History of anaphylaxis in association with previous administration of monoclonal antibodies. * Vaccination with a live vaccine within 28 days prior to start of therapy