The investigators want to learn more about obesity, the development of insulin resistance, and Type 2 Diabetes in children. The investigators will do this through collecting information about children's health and conducting experiments on a variety of samples.
Study Type
OBSERVATIONAL
Enrollment
79
Arkansas Children's Hospital
Little Rock, Arkansas, United States
Altered circulating blood cell bioenergetics
The investigators hypothesize that when compared to normal weight or obese insulin sensitive children, obese insulin resistant children will exhibit altered circulating blood cell bioenergetics.
Time frame: After completion of all study visits, approximately 2 years.
Oxidized plasma redox state
The investigators hypothesize that when compared to normal weight or obese insulin sensitive children, obese insulin resistant children will exhibit a more oxidized plasma redox state.
Time frame: After completion of all study visits, approximately 2 years.
Alterations in resting energy expenditure
The investigators hypothesize that when compared to normal weight or obese insulin sensitive children, obese insulin resistant children will be associated with alterations of decreased resting energy expenditure.
Time frame: After completion of all study visits, approximately 2 years.
Alterations in fatty acid oxidation
We hypothesize that when compared to normal weight or obese insulin sensitive children, obese insulin resistant children will be associated with alterations of impaired fatty acid oxidation (FAO).
Time frame: After completion of all study visits, approximately 2 years.
Poor oxidative capacity
The investigators hypothesize that poor oxidative capacity over time may distinguish between metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO) phenotypes.
Time frame: After completion of all study visits, approximately 2 years.
Predicting Type 2 Diabetes development
The investigators hypothesize that poor oxidative capacity over time may be predictive of Type 2 Diabetes development.
Time frame: After completion of all study visits, approximately 2 years.
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Bioenergetics in Type 2 Diabetes with metformin
The investigators hypothesize that the change in bioenergetics will be improved in obese Type 2 Diabetes children at 6 months of metformin therapy that will be prescribed as part of their clinical care.
Time frame: 6 months
Resting Energy Expenditure in Type 2 Diabetes with metformin
The investigators hypothesize that the change in resting energy expenditure will be improved in obese Type 2 Diabetes children at 6 months of metformin therapy that will be prescribed as part of their clinical care.
Time frame: 6 months
Fatty Acid Oxidation in Type 2 Diabetes with metformin
The investigators hypothesize that the change in fatty acid oxidation will be improved in obese Type 2 Diabetes children at 6 months of metformin therapy that will be prescribed as part of their clinical care.
Time frame: 6 months