The purpose of this study will be to examine the acute effect of commercially available energy products on endothelial function, arterial stiffness and thrombosis in healthy young males.
The use of energy products has significantly increased in the last few years and is especially high among young men. The present study will compare the acute effect of a commercially available energy drink, energy gum, coffee and control beverage on endothelial function, arterial stiffness and circulating markers of thrombosis, inflammation and oxidative stress.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
19
16 oz cold commercially-available energy drink
16oz cold commercially-available caffeinated drink
2 pieces of commercially-available energy gum
University of Florida
Gainesville, Florida, United States
Change in endothelial function
Brachial artery flow-mediated dilation
Time frame: Before and 1 and 2 hrs following consumption of drink and gum
Change in arterial stiffness
Carotid to femoral pulse wave velocity
Time frame: Before and 1 and 2 hrs following consumption of drink and gum
Change in wave reflection
Augmentation index
Time frame: Before and 1 and 2 hrs following consumption of drink and gum
Change in peripheral and central blood pressures
Brachial and aortic blood pressures
Time frame: Before and 1 and 2 hrs following consumption of drink and gum
Change in thrombosis and platelet function
Thromboelastograph and platelet aggregation tests
Time frame: Before and 1 and 2 hrs following consumption of drink and gum
Change in circulating factors related to vascular function
Circulating levels of Trimethylamine N-oxide (TMAO) and markers of oxidative stress and inflammation
Time frame: Before and 1 and 2 hrs following consumption of drink and gum
Change in heart rhythm
Electrocardiogram
Time frame: Before and 1 and 2 hrs following consumption of drink and gum
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2 pieces of commercially-available placebo gum
16oz cold control drink
24-hour total sleep deprivation prior to consumption of energy drink and placebo gum