This study aims to investigate the benefit of administering two differing doses of Bupropion (BUP) to smokers to assist with smoking cessation.
Participants will be randomly assigned to either receive 300 mg of BUP or 450 mg of BUP for 8 weeks with an aim to quit smoking. In addition, participants will simultaneously receive counseling to set a quit date and stay motivated to quit. Medication will be administered up to 4 weeks before and for 4 weeks after designated quit-date. Post-treatment follow-up appointment will be scheduled for 8, 16, and 26 weeks post treatment to assess commitment to quitting and overall success of the study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
12
Antidepressant that is also effective in smoking cessation
University of Southern California
Los Angeles, California, United States
Point Prevalence Abstinence (PPA) [change in abstinence reports will be assessed]
Self report of smoking status
Time frame: Through study completion, an average of 26 months
Smoking cessation milestones
Smoking timeline follow back interview
Time frame: Through study completion, an average of 26 months
Inventory of Depressive and Anxious Symptomology (General depression subscale)
This measure is obtained through the completion of the Inventory of Depressive and Anxious Symptomology General depression subscale. A total score will be calculated. Scores can range from 4 to 20 with the lower scores representing lower levels of depression and higher scores representing higher levels of depression.
Time frame: Through study completion, an average of 26 months
Inventory of Depressive and Anxious Symptomology (Social anxiety subscale)
This measure is obtained through the completion of the Inventory of Depressive and Anxious Symptomology Social anxiety subscale. A total score will be calculated. Scores can range from 4 to 20 with the lower scores representing lower levels of social anxiety and higher scores representing higher levels of social anxiety.
Time frame: Through study completion, an average of 26 months
Inventory of Depressive and Anxious Symptomology (Traumatic intrusions subscale)
This measure is obtained through the completion of the Inventory of Depressive and Anxious Symptomology Traumatic intrusions subscale. A total score will be calculated. Scores can range from 4 to 20 with the lower scores representing fewer traumatic intrusions and g scores representing greater traumatic intrusions.
Time frame: Through study completion, an average of 26 months
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Self report scale for Attention deficit/Hyperactivity disorder (ADHD)
ADHD symptom report
Time frame: Baseline visit
Snaithe-Hamilton Pleasure Scale (SHAPS)
Anhedonia scale
Time frame: Baseline visit and Week 8 post quit date
Objective body weight
Measured with a medical grade scale
Time frame: Baseline visit and Week 8 post quit date
Body adiposity via bioimpedence monitor
Measures body fat percentage/ BMI
Time frame: Baseline visit and Week 8 post quit date