The purpose of this study is to elucidate the effect of dexmedetomidine on renal function and delayed graft function after kidney transplantation
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
104
dexmedetomidine was infused at a rate of 0.4 μg/kg/h starting immediately after anesthetic induction and continued until skin closure.
0.9% NaCl was infused at a rate of 0.4 μg/kg/h starting immediately after anesthetic induction and continued until skin closure
Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine
Seoul, South Korea
RECRUITINGSerum creatinine level
Time frame: postoperative 7 day
incidence of delayed graft function
Time frame: 7 days after surgery
level of serum creatinine
Time frame: maximum 30 days before surgery, 1 hour after surgery, 1 day, 2 day, 3 day, 5 day, 7 day after surgery
blood urea nitrogen (BUN)
Time frame: maximum 30 days before surgery, 1 hour after surgery, 1 day, 2 day, 3 day, 5 day, 7 day after surgery
cystatin C
Time frame: maximum 30 days before surgery, 1 hour after surgery, 1 day, 2 day, 3 day, 5 day, 7 day after surgery
Neutrophil gelatinase-associated lipocalin (NGAL)
Time frame: maximum 30 days before surgery, 1 hour after surgery, 1 day, 2 day, 3 day, 5 day, 7 day after surgery
urine output
Time frame: during surgery, 1 day, 2 day, 3 day, 4 day, 5 day, 6 day, 7 day after surgery
fluid intake(intraoperative intake and output measured by the amount of fluid(crystalloid/colloid)(mL) and blood administered(mL))
Time frame: during surgery, 1 day, 2 day, 3 day, 4 day, 5 day, 6 day, 7 day after surgery
kidney ultrasound
Time frame: 1 week, 1 month after surgery, if possible
inflammatory mediator (IL-18, Il-1b) level
Time frame: immediately after induction, immediately after vessel clamp, immediately after reperfusion, 1hour after surgery
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