The Gut Microbiota and Delirium in the ICU

Herlev Hospital50 enrolled

Overview

To investigate whether the composition of the gut microbiota is different in patients that develop delirium during critical illness as compared to patients who do not.

We plan to include an equal number of patients admitted to the ICU, that either do or don't develop delirium during their course of critical illness. Samples of feces/rectal swaps will be taken at admission and again either when the patients become CAM-ICU positive, alternatively after 5 days admssion/at discharge in patients that remain CAM-ICU negative. Samples are then sent to analyses for purification of bacterial DNA and metagenomic analysis.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Delirium of Mixed Origin Microbial Colonization

Interventions

Metagenomic analysis of gut microbiotaDIAGNOSTIC_TEST

All patients have rectal swaps/fecal samples subjected to metagenomic analysis

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Admission to the ICU, Disability to make informed consent due to critical illness - Exclusion Criteria: Dementia. Delirium diagnosed prior to the ICU admission on the non-ICU floors. Coma. Indication for deep sedation (-4/-5). \-

Outcomes

Primary Outcomes

Gut Microbiota composition

Metagenomic analysis of Gut Microbiota / composition by different bacterial families

Time frame: May 2018

Data from ClinicalTrials.gov

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