The Combination Therapy of Fractional Laser and PRP Compared With Nanofat Grafting and PRP Synergy in Treating Striae Gravidarum.

First Affiliated Hospital of Jinan University10 enrolled

Overview

Nowadays, multiple treatment modalities have been applied clinically to treat striae gravidarum, such as laser therapy, microdermabrasion, platelet-rich plasma injection(PRP), etc. To some extent, these treatments can improve striae gravidarum. In this clinical trial, the investigators are going to treat striae gravidarum by using two different kinds of combination therapies. One is fractional laser and PRP injection synergy, and the other one is treated by nanofat grafting with PRP injection.

The investigators will pick out two areas of most severe striae gravidarum on a participant's abdomen. One of the areas will be treated by fractional laser once every three months for 2 times combined with PRP injection once a month for 6 times. Another area will be treated by nanofat grafting once every three months for 2 times and PRP therapy once a month for 6 times. The participants were asked to come back 1、3、6、9 months after treatment for further follow-up. Before and after the treatment, the striae gravidarum will be assessed subjectively by satisfaction assessment, dermatoscope and ultrasound, and objectively by immunohistochemical analysis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Treatments of Striae Gravidarum

Fractional CO2 LaserDEVICE

Fractional Carbon Dioxide Laser will be treated once every three months for 2 times.

Nanofat graftingPROCEDURE

Nanofat grafting will be applied once every three months for 2 times.

Platelet-rich plasma (PRP) InjectionPROCEDURE

PRP Injection will be applied once a month for 6 times.

Eligibility

Sex: FEMALEMax age: 35 Years

Medical Language ↔ Plain English

Inclusion Criteria: * The striae gravidarum was appeared within 3 years * Age ≤ 35 years old * Not in lactation * Not pregnancy within one year Exclusion Criteria: * Skin allergy * Skin inflammation or wound * Platelet dysfunction syndrome * Take anticoagulant drugs * Acute or chronic infection * Chronic liver disease * Photodermatosis * Active vitiligo, psoriasis, systemic lupus erythematosus * Other clinical trial

Outcomes

Primary Outcomes

Immunohistochemical analysis

The tissue extracted will be taken for immunohistochemical analysis to observe the change of epidermal and dermal thickness, and the distribution and amount of elastic fiber and collagen fiber,etc.

Time frame: Baseline and 15 months.

Secondary Outcomes

Dermatoscope

The striae gravidarum will be assessed by dermatoscope to observe the pigmentation condition of striae after the application of laser or nanofat grafting with PRP injection.

Time frame: Baseline and at 3,6,9,12,15 months after the treatments.

Ultrasound

The striae gravidarum will be assessed by ultrasound in order to observe the change of dermal thickness of striae after the application of laser or nanofat grafting with PRP injection.