Effectiveness and Safety of Berberine Hydrochloride and Bifidobacterium in People With Abnormal Glucose Level

Inclusion Criteria: * Informed consent obtained before any trial-related activities. * Male or female between 18 and 70 years of old. * 19≤Body mass index(BMI)≤30kg/m\^2. * No participate in any clinical trial at least 3 months. * Diagnosed impaired fasting glucose(IFG) and impaired glucose tolerance(IGT) or Diabetes. * In visit 1, 5.60mmol/L≤Fasting plasma glucose(FPG)\<8.0mmol/L; in visit 2, 6.1≤FPG\<8.0mmol/L or 7.8≤2-hour postprandial plasma glucose(2h-PPG) \<17mmol/L. * Females in child-bearing period should be given birth control. * No severe disease about heart, lung and kidney. Exclusion Criteria: * Type 1 diabetes * Diabetes patients with previously treated or untreated FPG ≥ 8 mmol/L or 2-h PPG ≥ 17 mmol/L; * Women of childbearing potential who are pregnant, breastfeeding or intend to become pregnant or are not using adequate contraceptive methods. * Those who are allergic to study drugs * Unable to cooperate * Abnormal liver function, ALT and AST are more than 2 times of the normal upper limit * Renal injury, blood creatinine ≥133 µmol/L * Poor blood pressure control, systolic blood pressure SBP≥160mmHg and/or diastolic blood pressure DBP≥95mmHg * Patients with chronic gastrointestinal diseases (pancreatitis, inflammatory bowel disease) and history of intestinal surgery * Patients with severe heart disease, such as heart failure, unstable angina pectoris, acute myocardial infarction * Chronic hypoxic diseases such as emphysema, pulmonary heart disease * Having obvious diseases of the blood system * Persons with tumor diseases * Endocrine diseases, such as hyperthyroidism and hypercortisolism * Mental illness, abuse of alcohol, drugs or other substances * Persons with long-term oral or intravenous corticosteroid hormones therapy * Having stress conditions such as surgery, severe trauma, etc.