Many patients with traumatic brain injuries (including strokes, blood clots, or other brain injuries) are given concentrated salt water solutions (hypertonic saline) in order to treat brain swelling (cerebral edema). Current therapies consist of a mixture of sodium and chloride, which can lead to high levels of serum chloride and increased total body water. High levels of chloride can cause acidosis, which can cause the body to function sub-optimally. Therefore, the investigators are proposing to use two concentrated solutions in these patients at the same time that will allow for a lower total volume of solution administration and reduce the rise in chloride to prevent acidosis. The main outcome will therefore be the patients sodium level, chloride level and serum pH.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
3% sodium chloride will be infused into patients for the treatment or prevention of raised intracranial pressure
23.4% sodium chloride will be infused into patients for the treatment or prevention of raised intracranial pressure
8.4% sodium bicarbonate will be infused into patients for the treatment or prevention of raised intracranial pressure
Stanford University Hospital
Stanford, California, United States
Total volume of intravenous hypertonic fluid administered to the patient
Total hypertonic fluid volume administered to each group of patients measured in milliliters of fluid.
Time frame: The fluid will be infused until the new serum sodium goal is achieved. This outcome measure will be assessed 1 week after study enrollment
Urine output
Urine output will be collected and measured quantitatively in milliliter units.
Time frame: Urine output during active hypertonic fluid infusion will be measured. This outcome measure will be assessed 1 week after study enrollment
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