This is an observational study at the Obstetrical outpatient clinic at Stavanger University Hospital. The main goal is to compare the current marker of glycemic control (glycated hemoglobin A1c, HbA1c) with glycated albumin in pregnancies with pregestational diabetes mellitus. Women with diabetes are at increased risk for adverse pregnancy outcomes. With improved glycemic control, the risk decreases. Glycated albumin is suggested to be a better marker for monitoring glycemic control in pregnancies because it reflects blood glucose for a shorter period than HbA1c (3 versus 8-12 weeks). Other studies have shown that HbA1c increases in pregnancy because of iron deficiency. The investigators want to investigate HbA1c, glycated albumin and iron status in diabetic pregnancies. The investigators will compare HbA1c and glycated albumin throughout pregnancy with the patient's own blood glucose measurements or data from CGM (continuous blood glucose monitoring). Blood samples for HbA1c and glycated albumin will be taken 6 times during pregnancy (week 12, 20, 24, 28, 32, 36).
Study Type
OBSERVATIONAL
Enrollment
41
Stavanger University Hospital
Stavanger, Rogaland, Norway
Glycemic Control markers in pregnancy
Compare HbA1c and glycated albumin to blood sugar measurements
Time frame: throughout pregnancy, gestational week 12-36.
Iron status in diabetic pregnancy,
Compare current markers of iron status with hepcidin throghout diabetic pregnancies by analyses of blood samples in gestational week 12, 20, 24, 28, 32 and 36.
Time frame: throughout pregnancy, gestational week 12-36.
Preterm delivery
Register pregnancy outcomes. Delivery before gestational week 37 will be registered. Data will be collected from journals.
Time frame: at delivery.
Preeclampsia
Register pregnancy outcomes. New onset systolic blood pressure \>140, diastolic blood pressure \>90 after gestational week 20 and proteinuria 2+ according to urine dipstick, will be registered as preeclampsia
Time frame: From gestational week 20 to 1 week after delivery.
Induction of labour
Register pregnancy outcome. Induction of Labour and indication for induction will be registered.
Time frame: At delivery.
APGAR
Register pregnancy outcome. APGAR score (Appearance, Pulse, Grimace, Activity, Respiration) of the newborn will be registered for 1 minute, 5 minute and 10 minutes after delivery.
Time frame: At delivery.
Birth weight
Register pregnancy outcome. Birth weight (gram) of the newborn will be registered.
Time frame: At delivery.
Admission to neonatal intensive care unit
Register pregnancy outcome. Admission to neonatal intensive care unit will be registered.
Time frame: At delivery.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.