The purpose of the present study is to determine if use of dietary supplement tauroursodeoxycholic acid enhances insulin-stimulated leg blood flow and glucose disposal.
The notion that cellular stress lowers insulin-induced vasodilation is largely founded on ex vivo studies and experiments in rodents. However, it remains unknown if maintenance of cellular function with the use of dietary supplement tauroursodeoxycholic acid enhances vascular function in humans. The investigators test the hypothesis that daily administration of this dietary supplement enhances vascular function, particularly, insulin-stimulated leg blood flow and glucose disposal.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
8
Taking tauroursodeoxycholic acid (1750 mg/day) capsules for 4 weeks.
Taking daily placebo capsules for 4 weeks.
University of Missouri
Columbia, Missouri, United States
Blood flow
Blood flow response during insulin clamp
Time frame: Once at 4 weeks after the start of placebo and once at 4 weeks after the start of tauroursodeoxycholic acid
Vascular function
Flow-mediated dilation
Time frame: Once at 4 weeks after the start of placebo and once at 4 weeks after the start of tauroursodeoxycholic acid
Insulin resistance
Glucose disposal rate during insulin clamp
Time frame: Once at 4 weeks after the start of placebo and once at 4 weeks after the start of tauroursodeoxycholic acid
Glucose tolerance
Glucose response to an oral glucose tolerance test
Time frame: Once at 4 weeks after the start of placebo and once at 4 weeks after the start of tauroursodeoxycholic acid
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.