As a follow-on study to NCT01416038, this study is designed to identify the optimal dosage of immunotherapeutic survivin vaccine DPX-Survivac and low dose oral cyclophosphamide. The combination treatment is being evaluated in a non-randomized, multi-cohort study as post-chemotherapy treatment for patients with late-stage ovarian, fallopian tube, or peritoneal cancer.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
37
SubQ injection
SubQ injection
PO BID
Winthrop University Hospital
Mineola, New York, United States
Lenox Hill Hospital
New York, New York, United States
Princess Margaret Cancer Centre
Toronto, Ontario, Canada
Safety as measured by adverse event reporting (CTCAE)
Time frame: up to 11 months
Cell mediated immunity as measured by the antigen specific response in peripheral blood
Time frame: up to 11 months
Impact on residual tumour
Evaluated by standard of care radiology and CA-125
Time frame: up to 11 months
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