The effect of vitamin D3 and omega-3 Fatty acids on estradiol levels.
The data about effect of vitamin D3 (VD3) and omega-3 fatty acids (omega-3FA) on serum levels of estradiol (E2) are scarce and conflicting and nothing is published in the literature about the effect of the combination of VD3 and omega-3FA on the E2 levels. This study was conducted to investigate effect of VD3 and omega-3FA alone and with each other on serum E2 levels in premenopausal females with vitamin D deficiency (VDD). This randomized, placebo-controlled clinical trial was designed to test effects of 50,000 IU VD3 weekly and 300 mg omega-3FA daily for eight weeks, separately and with each other, on the mid-follicular serum levels of E2 and 25-hydroxy vitamin D (25OHD). This study was conducted during winter in 86 healthy premenopausal Jordanian females with VDD with a mean age of (32.8 ± 8.9) years. Fasting serum levels for 25OHD, E2, PTH (parathyroid hormon), calcium, phosphate, ALT (alanine aminotransferase), and urea were assessed at baseline and the end of the trial.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
116
50,000 IU VD3 / week for 8 weeks
300 mg of omega3-FA once daily for 8 weeks
50,000 IU VD3 / week for 8 weeks and 300 mg of omega-3FA once daily for 8 weeks
Plasma concentrations of 25-hydroxyvitamin D, estradiol
Concentration
Time frame: 8 weeks
Plasma concentrations of PTH, Ca
Concentration
Time frame: 8 weeks
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No intervention was given