Study of VTD in Waldenstrom's Macroglobulinemia

Inclusion Criteria: * Age of 19 or older * Newly diagnosed Waldenstrom's macroglobulinemia or lymphoplasmacytic lymphoma * Previously untreated with chemotherapy * ECOG performance status of 2 or lesser * Peripheral blood white blood cell count ≥ 3,500/uL * Peripheral blood neutrophil count ≥ 1,000/uL * Peripheral blood platelet count ≥ 20,000/uL * Peripheral blood hemoglobin ≥ 6.0g/dL * Serum total bilirubin ≤ 2.0 mg/dL * Serum aspartate aminotransferase ≤ 2.5 x (upper normal limit) * Serum alanine aminotransferase ≤ 2.5 x (upper normal limit) Exclusion Criteria: * Diagnosed with other malignancy within 5 years before enrollment * Prior hematopoietic stem cell transplantation * Prior organ transplantation * Uncontrolled central nervous system involvement * Congenital immunodeficiency * Acquired immune deficiency syndrome (AIDS) * Pregnancy * Uncontrolled epilepsy * Uncontrolled psychological disease * Peripheral neuropathy of grade 3 or higher