Determining Drug Levels of Beta-lactam Antibiotics in Severe Burned Patients

University Hospital Schleswig-Holstein35 enrolled

Overview

At antibiotic stewardship of the University Hospital of Schleswig-Holsten it was noticed that there are much less studies measuring drug levels in severe burned patients than are required. Especially, severe burned patient developing a capillary leak might show lower drug levels than patients without a capillary leak. To compare drug levels of beta-lactam antibiotics, it is the aim of this study to measure pharmacokinetics of Piperacillin/Tazobactam in ICU patients with and without severe burns.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Antibiotics Severe Burn Intensive Care

Interventions

Drug Level MonitoringDIAGNOSTIC_TEST

Free (unbound) drug concentration 1 hour, 4 hours and 7.5 hours after primary load of piperacillin/tazobactam on day 1 and day 3 after admission

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: General * Adult * Receiving beta-lactam antibiotic Piperacillin/Tazobactam * Antibiotic therapy of 3 or more days * Given informed consent Group 1 * Severe Burn Group 2 * No Severe Burn Exclusion Criteria: * Already in another Study * No useful blood sample

Outcomes

Primary Outcomes