Feasibility of Telerehabilitation in HIV-patients

Cliniques universitaires Saint-Luc- Université Catholique de Louvain25 enrolled

Overview

The aim of this study is to assess the feasibility and the effects of a 6-week telerehabilitation on the three domains of the International Classification of Functioning, Disability and Health in HIV-infected patients under highly active antiretroviral therapy (HAART). HIV-infected patients were randomized either into an Endurance and Resistance Training Exercise (ERTE) group or a control (CON) group. Telerehabilitation was realized in a public fitness center, with online guidance and weekly telephone advice, 3 times per week for 6 weeks. Feasibility was determined by recruitment rate, retention rate and adverse events. Secondary outcomes were impact on body composition, inflammation and coagulation (C-reactive protein, D-dimer), physical fitness and quality of life (WHOQOL-HIV).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Human Immunodeficiency Virus

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years or older * under HAART treatment * native French speaker Exclusion Criteria: * AIDS diagnosis * physical and/or psychiatric impairments that seriously impaired physical activity * pregnant * Unstable (defined by any modification of health outcomes during the last 6 months).

Outcomes

Primary Outcomes

Recruitment rate

Number of eligible participants who enrolled in the program out of the number were recruited

Time frame: At study completion (after 6 weeks)

Retention rate

Percentage of patients lost to follow-up

Time frame: At study completion (after 6 weeks)

Adverse events

Percentage of patients who experienced one or more adverse events

Time frame: At study completion (after 6 weeks)

Secondary Outcomes

Weight

Weight (kg) is measured by using a bioelectrical impedance analysis

Time frame: Assessments at baseline and at 6 weeks

Lean body mass

Lean body mass (kg) is measured by using a bioelectrical impedance analysis

Time frame: Assessments at baseline and at 6 weeks

Fat body mass

Lean body mass (kg) is measured by using a bioelectrical impedance analysis

Time frame: Assessments at baseline and at 6 weeks

C-reactive protein

C-reactive protein is measured by a blood test

Time frame: Assessments at baseline and at 12 weeks

D-dimer

D-dimer is measured by a blood test

Time frame: Assessments at baseline and at 12 weeks

CD4+ T cell counts

CD4+ T cell counts is measured by a blood test

Time frame: Assessments at baseline and at 12 weeks

Viral load

Viral load is measured by a blood test

Time frame: Assessments at baseline and at 12 weeks

Functional exercise capacity

Functional exercise capacity is measured by a 6-minute walk test

Time frame: Assessments at baseline and at 6 weeks

Flexibility

Flexibility is measured by Toe touch test and sit and reach test

Time frame: Assessments at baseline and at 6 weeks

Lower body muscular strength

Lower body muscular strength is measured by 30-s chair-stand test

Time frame: Assessments at baseline and at 6 weeks

Upper limb strength

Upper limb strength is measured by hand grip strength tool

Time frame: Assessments at baseline and at 6 weeks

Quality of life

Quality of life is measured by World Health Organization Quality of Life HIV Instrument

Time frame: Assessments at baseline and at 6 weeks