GALNT4 in Patients With Acute Coronary Syndrome

The First Affiliated Hospital of Dalian Medical University100 enrolled

Overview

The expression of GALNT4 in blood with acute coronary syndrome

Emerging evidences have linked GALNTs to cardiovascular disease or susceptibility to CAD.GALNT4, a member of the GalNAc-Ts family,contributes to the initiation of O-linked. Polymorphisms in GALNT4 have been linked with incidence of MI in an Irish population, probably that O-glycosylation of PSGL-1 by GalNAc-T4 may be important for many P-selectin mediated inflammation.However, there is few relevant studies about the expression of GALNT4 in patients with acute coronary syndrome.This study valuates the expression of GALNT4 in patients with acute coronary syndrome.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Acute Coronary Syndrome

Interventions

expression of GALNT4DIAGNOSTIC_TEST

Blood is obtained into ethylenediaminetetraacetic acid（EDTA） tubes from all subjects via antecubital venepuncture and the total RNA was extracted from blood.Realtime PCR was performed to measure the expression of GALNT4.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * diagnosed as acute coronary syndrome,including STEMI,NSTE-ACS,or diagnosed as SAP by CAG. * with left ventricular ejection fraction（LVEF）\>=45% * written informed consents are obtained * admitted within 24 hours after chest pain attacked(except SAP) Exclusion Criteria: * • complicated with rheumatic heart disease, coronary arteritis, hypertrophic cardiomyopathy or dilated cardiomyopathy * complicated with malignant tumor,the immune system diseases, blood system diseases, recently (within 2 weeks) taking glucocorticoid drugs, the use of immunosuppressive agents and cerebral infarction * with acute or chronic infection, surgery or trauma in the last month * secondary hypertension, severe liver dysfunction,severe renal insufficiency * with abnormal thyroid function or allergy to iodine agent * refusal to sign the informed consent

Locations (1)

The First Affiliated Hospital of Dalian Medical University

Dalian, Liaoning, China

Outcomes

Primary Outcomes

the expression of GALNT4

Realtime RCR measure the expression of galnt4 in peripheral blood

Time frame: 12 months

Secondary Outcomes

MACEs during 12-month follow-up

All major adverse cardiac events( MACEs) including death, myocardial infarction, heart failure are recorded

Time frame: 12 months

Data from ClinicalTrials.gov

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