The purpose of this study is to evaluate the treatment of solid tumors with various immunotherapy combinations. The treatment will be determined based upon a broad biomarker assessment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
20
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Specified dose on specified day
Specified dose on specified day
Local Institution - 0001
Chicago, Illinois, United States
University of Chicago
Chicago, Illinois, United States
Local Institution - 0002
Baltimore, Maryland, United States
Local Institution - 0003
Pittsburgh, Pennsylvania, United States
Number of participants with qualified tumor biopsy specimen at baseline
An adequate quality tumor biopsy providing sufficient information prior to choosing a combination immunotherapy/Stereotactic Body Radiation Therapy (SBRT)
Time frame: Up to 28 days
Percent of change from baseline in histopathologic features
Time frame: Up to 4 years
Percent of change from baseline in biomarker expression patterns
Time frame: Up to 4 years
Number of Adverse Events (AEs)
Time frame: Up to 4 years
Number of Serious Adverse Events (SAEs)
Time frame: Up to 4 years
Number of Laboratory Abnormalities
Any laboratory test result that is clinically significant or meets the definition of an SAE, requires the participant to have study treatment discontinued, or receive specific corrective therapy
Time frame: Up to 4 years
Number of Adverse Events(AEs) leadind to discontinutaion
Number of Adverse Events leadind to discontinutaion
Time frame: up to 4 years
Number of Deaths
Time frame: up to 4 years
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Specified dose on specified day
Specified dose on specified day
Specified dose on specified day