CORT125281 Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD)

Inclusion Criteria: 1. Give written informed consent 2. If male, have undergone vasectomy, with no wish to have the procedure reversed 3. If female, using appropriate precautions to avoid pregnancy, defined as of nonchildbearing potential (ie, postmenopausal or permanently sterilised) or using highly effective contraception with low user-dependency * A woman is postmenopausal if it is more than 12 months since her last menstruation, without an alternative medical cause. A concentration of FSH in the postmenopausal range may be used to confirm a postmenopausal state in women not using hormonal contraception or hormonal replacement therapy. * Accepted methods of permanent sterilization methods are hysterectomy, bilateral salpingectomy and bilateral oophorectomy. * An IUD is the only acceptable method of highly effective contraception with low user-dependency, provided that the subject has tolerated its use for at least 3 months before the first dose of study medication and undertakes not to have it removed for 1 month after the last dose. 4. Be aged 18 to 65 years inclusive 5. Have a BMI of 19 to 30 kg/m2, inclusive 6. Be willing to comply with study restrictions as described in Section 4.6 7. Be able to comply with the requirements of the entire study 8. Be judged to be in good health, based upon the results of a medical history, physical examination, vital signs, 12-lead ECG, and clinical laboratory findings 9. For multiple dose cohorts, have a morning serum cortisol within the local reference range at screening and/or Day -1 10. Have suitable veins for multiple venepunctures/cannulation 11. Be able to swallow size 0 capsules whole Exclusion Criteria: 1. Be an employee or immediate family member of the CRU or Corcept 2. Have been previously enrolled in this study 3. Have multiple drug allergies, or be allergic to any of the components of study medication, its matching placebo, challenge agents or probe substrates (see Section 5.1) 4. Have a condition that could be aggravated by glucocorticoid blockade (eg, asthma, any chronic inflammatory condition) or activation (eg, immunodeficiency, active infection) Subjects with inactive seasonal hay fever may be included. Subjects with childhood (aged less than 18 years) asthma may be included provided they have had no symptoms and required no treatment for at least 5 years 5. In the 6 calendar months before study drug administration, on average * Have smoked more than 5 cigarettes/day * Have consumed more than 14 units (female) or 21 units (male) of alcohol/week * Consumed liquorice or other glycyrrhetic acid derivatives regularly, in the judgement of the Investigator 6. In the 3 calendar months before study drug administration * Have donated blood or plasma in excess of 400 mL * Have participated in another clinical trial of a new chemical entity or a prescription medicine 7. Have a positive test for alcohol, smoking or drugs of abuse at screening or admission to any of the dosing sessions 8. Have clinically-relevant abnormal findings on vital signs, physical examination, laboratory screening tests, or 12-lead ECG, at screen and/or before first dose, including but not limited to: * Abnormal ECG waveform morphology that would preclude accurate measurement of the QT interval * QTcF \>450 ms (from mean of 3 supine ECGs, performed at least 2 minutes apart) * Stage 2 or higher hypertension (supine/semi-recumbent systolic blood pressure \[SBP\] \>160 mmHg; diastolic blood pressure \[DBP\] \>100 mmHg, based on mean of duplicate values recorded at least 2 minutes apart) * Stage 1 hypertension (supine/semi-recumbent SBP 140-160 mmHg; DBP 90-100 mmHg, based on mean of duplicate values recorded at least 2 minutes apart) associated with indication for treatment ie, evidence of end-organ damage, diabetes or a 10 year cardiovascular risk, estimated using a standard calculator eg, QRisk2 2016 \>20% * Glomerular filtration rate, estimated using the chronic kidney disease epidemiology (collaboration) (CKD-EPI) method (eGFR; see Section 6.2.5) \<60 mL/minute/1.73 m2 * Hypokalaemia (potassium below lower limit of normal) * ALT, AST and/or gammaglutamyl transferase (GGT) \>1.5 times the upper limit of normal * Seropositive for hepatitis B, hepatitis C or human immunodeficiency viruses. 9. Have any medical or social reasons for not participating in the study raised by their General Practitioner/primary care physician 10. Have any other condition that might increase the risk to the individual or decrease the chance of obtaining satisfactory data, as assessed by the Investigator 11. Taken any prohibited prior medication, as described in Section 4.6.3