This study included two groups of premenopausal healthy obese women. Experimental group underwent a weight loss program involved a low calorie diet plus anti-obesity drugs and moderate physical activity and control group underwent an ad libitum diet. At baseline and after a 10-15% weight loss lymphocyte subgroups were analyzed and compared between two group.
TCD3 and NKC CD16/56 were decreased significantly. Hence this weight loss program impaired viral immunity
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Enrollment
29
A low calorie diet+ Orlistat+ Soluble Fiber+ Physical activity
lymphocyte subgroups
TCD3. TCD4. TCD8. BCD19. NKCs CD16/56 (Cells/microliter) by flowcytometry
Time frame: 6 months
Body Mass Index
(Kg/m\^2) by equation
Time frame: 6 months
Biomarkers
ZN, Iron (microgram/deciliter) by biochemical assessment
Time frame: 6 months
Systolic blood pressure
(mmHg) by manometer
Time frame: 6 months
diastolic blood pressure
(mmHg) by manometer
Time frame: 6 months
Weight
(Kg) by Bioelectric impedance analyser
Time frame: 6 months
Fat Mass
(Kg) by Bioelectric impedance analyser
Time frame: 6 months
Fat Free Mass
(Kg) by Bioelectric impedance analyser
Time frame: 6 months
Trunk Fat
(Kg) by Bioelectric impedance analyser
Time frame: 6 months
Waist circumference
(cm) by meter tape
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Time frame: 6 months