Intratumoral Budding (ITB) in Preoperative Biopsies of Colon and Rectal Cancer

N/AActive Not RecruitingNCT03336658

Insel Gruppe AG, University Hospital Bern150 enrolled

Overview

All the preoperative biopsies of patients suffering colorectal cancer (CRC) will be immunohistochemically stained with a pancytokeratin marker to detect Tumor buds. then, the intratumoral buds (ITB) in the densest Region of Tumor buds, namely the "hot spot" will be counted. Subsequently, the probability of N stage (lymphnodes), M stage (metastases) and disease free survival (DFS) will be calculated based on an existing logistic Regression model already developed by our previous retrospective work. Additionally, a Standardisation of ITB using a well- established Software will develop an algorithm which will help to eliminate inter- observer variability of Tumor budding Counts.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

CRC

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with newly diagnosed stages I and IV colorectal cancer (CRC) * Age ≥ 18 years * Written Informed Consent Exclusion Criteria: * No consent * \< 18 years

Locations (1)

Department of visceral surgery and transplant surgery, Berne University Hospital

Bern, Switzerland

Outcomes

Primary Outcomes

correlation of ITB based calculated N stage with real N stage in CRC - patients

Time frame: 24 months

Secondary Outcomes

correlation of ITB based calculated DFS with real DFS in CRC - patients

Time frame: 24 months