The Effect of Propofol or Sevoflurane on Renal Function

Uppsala University37 enrolled

Overview

This study investigates the role of the anesthetic agents propofol and sevoflurane on renal function in otherwise healthy patients undergoing basic back surgery.

Water-sodium homeostasis is central for anyone undergoing surgery, and can therefore affect surgical outcome, level of postoperative care and the length of hospital stay. Too much or too little fluid during surgery can affect the patients negatively. The kidneys play an imperative role in the regulation of water and sodium homeostasis, however there are lack of knowledge in how the anesthesia per se affects renal function. Previous studies have shown that volatile anesthetic agents such as sevoflurane can cause fluid retention. Why this happens is not completely known. We are now investigating the different affects of sevoflurane and propofol anesthesia on renal function in patients undergoing basic back surgery to elucidate if there is a difference in the risk of developing acute kidney injury.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Acute Kidney Injury Anesthesia

Interventions

Back SurgeryPROCEDURE

All patients undergo basic back surgery.

PropofolDRUG

Anesthesia on propofol alone.

SevofluraneDRUG

Anesthesia on sevoflurane alone.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Scheduled back surgery Exclusion Criteria: * American Association of Anesthesiology class 1-3 * American Heart Association class \>3 * BMI \>37 * Insulin treated diabetes * Pregnancy or breast feeding * Sensistivity/allergy against anesthetic agents * Inadequate understanding about the study * Depressed kidney function and/or AKI * Depressed liver function * Genetic malignant hyperthermia

Locations (1)

Akademiska sjukhuset, Centraloperation

Uppsala, Sweden

Outcomes

Primary Outcomes

Change in urine output

Urine output (ml/min) changes during anesthesia, in postoperative care and in the ward unit. Changes will be assessed with AKIN RIFLE and by comparison between the different groups.

Time frame: 24 hours

Change in serum creatinine levels

Changes in serum creatinine levels during anesthesia, in postoperative care and in the ward unit. Changes will be assessed with AKIN RIFLE and by comparison between the different groups.

Time frame: 24 hours

Change in creatinine clearance

Creatinine clearance changes during anesthesia, in postoperative care and in the ward unit. Changes will be assessed with AKIN RIFLE and by comparison between the different groups.

Time frame: 24 hours

Secondary Outcomes

Changes in electrolytes

Changes in serum and urinary electrolytes (sodium and potassium) will be measured during anesthesia, in postoperative care and in the ward unit.

Time frame: 24 hours

Changes in hormone levels

The hormones angiotensin II, anti diuretic hormone and aldosterone will be measured during anesthesia, in postoperative care and in the ward unit.

Time frame: 24 hours

Data from ClinicalTrials.gov

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