In Vivo Determination of Cytochrome P450 Activities in Patients With Liver Cirrhosis

Inclusion Criteria: * Full mental and legal capacity. * Signed informed consent prior to any study related procedure. * Ability to communicate in German, sufficient to comprehend and adhere to study protocol. * Normal physical examination, vital signs, laboratory workup, and CombiCaps LC Study Protocol Version 1.2 09.08.2017 Page 9 of 50 electrocardiogram (ECG) (in the opinion of investigator). * Hematology and clinical chemistry results not deviating from the normal range to a clinically relevant extent at screening (in the opinion of investigator). * No other conditions or circumstances that might interfere with compliance with study protocol (in the opinion of investigator). Exclusion Criteria: * Known hypersensitivity to probe substances or any excipient of the drug formulation. * Ongoing or past treatment with another investigational drug within 30 days prior to screening. * Concomitant treatment with drugs that inhibit or induce CYP3A4, CYP2D6, CYP2C9, CYP2C19, CYP2B6 and CYP1A2 function (in the opinion of investigator). * Actual infection * Severe heart failure (NYHA IV). * Actual alcohol or drug abuse * Positive results from urine drug screen at screening. * Excessive caffeine consumption, defined as \>800 mg per day at screening\*. * Subjects unwilling to stop consumption of alcoholic- and caffeine-containing beverages on study days until after the last sampling time-point of the study period. * Intake of food products (immediately before or during study) known to be inducers or inhibitors of CYP450 (e.g. grapefruit juice) * Loss of 250 ml or more of blood within 3 months prior to screening. * Pregnant or lactating women * Any circumstances or conditions, which, in the opinion of the investigator, may affect full participation in the study or compliance with the protocol. * Legal incapacity or limited legal capacity at screening. \*100 mg caffeine is approximately 1'000 ml Coca Cola®, 2½ espresso cups or 1 cup of strong coffee.