Platelet Function With Various Storage Techniques

Northwell Health

Overview

Platelet function will be tested in individuals on antiplatelet medications to determine the optimal storage methodology.

Subjects will undergo administration of antiplatelet drugs and then will receive platelets stored in a variety of methods. Platelet function will be measured serially.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Conditions

Platelet Dysfunction Due to Drugs

Interventions

Infusion of PlateletsBIOLOGICAL

Platelets will be stored using novel, FDA approved, technique. Subjects will receive infusion of platelets stored by novel technique, routine storage, and placebo (saline).

Infusion of PlateletsBIOLOGICAL

Platelets will be stored using the routine platelet storage method. Subjects will receive infusion of platelets stored by routine storage method.

PlaceboBIOLOGICAL

Subjects will receive infusion placebo (saline).

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Normal subjects Exclusion Criteria: * Pre existing antiplatelet drugs

Outcomes

Primary Outcomes

Change in platelet function

Frozen platelets will result in improvement in platelet function after transfusion.

Time frame: 1 hour post-transfusion

Data from ClinicalTrials.gov

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