The Effect of Esophageal Doppler Guided Goal-directed Hemodynamic Therapy in Severe Trauma Patients

Ajou University School of Medicine46 enrolled

Overview

Prospective randomized clinical trial Compare the goal-directed fluid therapy using esophageal Doppler and classic fluid therapy

Goal directed fluid therapy becomes issue for enhanced recovery after surgery. In goal directed therapy, dynamic parameters, like stroke volume and cardiac output, is important. Esophageal Doppler is one of device which provides dymanic parameters. In severe trauma cases, the effect of goal directed therapy is not known yet. So the aim of this study is comparing the results of goal directed therapy using esophageal Doppler and conventional fluid therapy.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Trauma

Interventions

esophageal DopplerDEVICE

Goal directed fluid therapy using dynamic parameters from esophageal Doppler

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Severe trauma patients who undergo general anesthesia * Initial serum lactate level \> 2mmol/L Exclusion Criteria: * Severe traumatic brain injury * THoracic surgery * Age \< 19 years old * Impending arrest or post CPR state * Severe facial trauma

Locations (1)

Ajou university school of medicine

Suwon, Gyeonggi-do, South Korea

Outcomes

Primary Outcomes

Lactate

Unit is mmol/L Inclusion criteria is initial lactate \> 2mmol/L. Whole hospital use same device and unit to measure lactate. In this study, POCT lactate won't be used. After surgical resuscitation, lactate level is independent predictor of survival, because it represents tissue oxygenation.

Time frame: Immediate postoperative (=initial ICU admission)

Secondary Outcomes

Acute Physiology and Chronic Health Evaluation II (APACHE II) score

ICU patient scoring system, score from 0 to 71, higher scores correspond to more severe disease and a higher risk of death

Time frame: Immediate postoperative

Creatinine

Kidney function

Time frame: Immediate postop

Data from ClinicalTrials.gov

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