Systemic sclerosis is a rare pathology characterized by fibrosis and vascular lesion with skin, pulmonary, digestive and cardiac localisation. Calcinosis cutis is commonly described, but its prevalence and appear few documented in literature. Moreover, this studies used clinical observation to determine presence or absence of calcification, and rarely radiography, in particular for feet localisation. In the same way, skin calcification and organ injury association appear unclear. The aim of the study is firstly to determine prevalence of calcinosis cutis, with hand and feet radiography realisation in a cohort of systemic sclerosis patient. Secondly, will be determine the correlation between calcinosis and organ injury.
Study Type
OBSERVATIONAL
Enrollment
214
Radiography of the hand and feet (face incident) the day of the inclusion
Blood sample to analysis VEGF, endothelin 1, endostatin and P/GF, (ELISA method)
Hôpital Claude Huriez, CHU
Lille, France
Calcinosis cutis prevalence by radiographic assessment
Time frame: at inclusion ( baseline)
Demographic data
Time frame: at inclusion ( baseline)
Rodnan score
Time frame: at inclusion ( baseline)
Visceral localisation evaluation (cardiac, pulmonary, digestive)
Time frame: at inclusion ( baseline)
EUSTAR score
Time frame: at inclusion ( baseline)
Medsger score
Time frame: at inclusion ( baseline)
Quality of life evaluation (HAQ modified questionary)
Time frame: at inclusion ( baseline)
Biologic vascular markers : VEGF, endothelin 1, endostatin and P/GF, (ELISA method)
Time frame: at inclusion ( baseline)
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