The Effect of an Oral Supplement,TK3 (Tryptophan and Thiamine) on the Quality of Life and Chemotherapy Tolerance in Cancer Patients With Advanced Disease.

Inclusion Criteria: * Patients who agree to study procedures and sign the informed consent * Patients 18 years of age or older; * Patients undergoing oncologic treatment for advanced neoplasms. It is understood by advanced patient disease patients with unresectable or with distant metastases. * Participants should present at least one (1) of the following clinical side effects that can be assessed according to CTCAE (Version 4.0): fatigue, nausea, vomiting, diarrhea, or mucositis. * Patients with programming to receive at least 3 cycles of anti-neoplastic chemotherapy; * Patients may be on radiotherapy Exclusion Criteria: * Use of vitamin complex or concomitant food supplement; * Current use or programming of parenteral diet use; * Hypersensitivity to the components of the formula; * Participation in another clinical study or use of any investigational product within 28 days prior to commencement of treatment in this clinical trial, unless the Investigator deems there to be a clinical benefit therefore;