Serum Concentration of Wnt2 and Wnt4 in Patients With Acute Coronary Syndrome

The First Affiliated Hospital of Dalian Medical University450 enrolled

Overview

This study aims to find the change of serum wnt effectory moleculars and the association with Hs-CRP，cTnI and Prognosis in Patients with Acute Coronary Syndrome.

It has been reported that wnt effecory moleculars (wnt2, wnt4, wnt11,wnt10b, DKK1, DKK2) increased in myocardium at acute phase after myocardium infarction in animal experiment. These moleculars can be detected in serum or plasma from human subjects. However, there is few relevant studies about wnt2 and wnt4 concentration in patients with acute coronary syndrome. This study valuates the serum wnt2 and wnt4 concentration in patients with acute coronary syndrome. It will possibly enable to find the relationship between serum wnt2 or wnt4 concentration and Hs-CRP, cTnI and prognosis in patients with Acute Coronary Syndrome.

Study Type

OBSERVATIONAL

Enrollment

450

Conditions

Acute Coronary Syndrome

Interventions

Circulating wnt 2 and wnt 4 concentrationOTHER

Blood (150 each group) is obtained into ethylenediaminetetraacetic acid（EDTA） tubes from all subjects via antecubital venepuncture to explore circulating wnt 2 and wnt 4 concentration by ELISA. Continuous wnt2 and wnt4 concentration are measured in all patients with STEMI at 0 , 7days and 12 months after admission. Other patients with acute syndrome system are measured Wnt 2 and wnt4 only once within 24h after admission. Wnt2 and wnt4 concentration in Control group will be measured only once with 24h after admission.

Eligibility

Sex: ALLMin age: 40 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: .diagnosed as acute coronary syndrome, including STEMI and NST-ACS. * with left ventricular ejection fraction（LVEF）\>=45% * written informed consents are obtained * admitted within 24 hours after chest pain attacked Exclusion Criteria: * • complicated with rheumatic heart disease, coronary arteritis, hypertrophic cardiomyopathy or dilated cardiomyopathy * complicated with malignant tumor,the immune system diseases, blood system diseases, recently (within 2 weeks) taking glucocorticoid drugs, the use of immunosuppressive agents and cerebral infarction * with acute or chronic infection, surgery or trauma in the last month * secondary hypertension, severe liver dysfunction,severe renal insufficiency * with abnormal thyroid function or allergy to iodine agent refusal to sign the informed consent

Locations (1)

The First Affiliated Hospital of Dalian Medical University

Dalian, Liaoning, China

Outcomes

Primary Outcomes

Serum wnt2 and wnt4 concentration

Serum wnt2 and wnt4 concentration in ng/ml

Time frame: 12 months

Secondary Outcomes

Relationship between wnt2 or wnt4 and high sensitive C reaction protein (hs-CRP) concentration

Correlation of wnt2 and wnt4 with hs-CRP concentration

Time frame: 12 months

Relationship between wnt2 or wnt4 and Troponin-I (Tn-I) concentration

Correlation of wnt2 and wnt4 with Tn-I concentration

Time frame: 12 months

MACEs during 12-month follow-up

Association of wnt2 or wnt4 concentration with prognosis

Time frame: 12 months

Data from ClinicalTrials.gov

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