Intravenous Administration of Insulin and Plasma Exchange on Triglyceride Levels in Early Stage of Hypertriglyceridemia-induced Pancreatitis

Inclusion Criteria: 1. Adult aged 18 to 80 years old; 2. abdominal pain consistent with AP; 3. serum amylase and / or lipase activity is at least 3 times higher than the normal upper limit; 4. abdominal imaging consistent with AP imaging changes. 5. severe hyperlipidemia "fasting serum TG\> 1,000 mg/dL (11.2mmol/L)"; 6. except for other AP causes, such as cholelithiasis, alcohol, drugs and so on. Exclusion Criteria: 1. other etiologies other than hyperlipidemia leading to AP; 2. fasting serum TG less than 1,000 mg / dL (11.2mmol / L); 3. acute lipid-induced pancreatitis at the same time combined with other etiologies of acute pancreatitis. 4. the existence of plasma replacement contraindications: serious allergies to plasma, human serum albumin, heparin and others; the existence of mental disorders; unstable heart or cerebral infarction; intracranial hemorrhage or severe cerebral edema associated with hernia. 5. without informed consent, the patient refused to plasma replacement, and other circumstances may bring significant bias.