Impact of Muscular Fatigability on Spastic Co-contractions After Stroke Patients

University Hospital, Lille30 enrolled

Overview

This study evaluates the effects of an isokinetic fatigue protocol of the quadriceps on the amount of co-contractions of this last with the hamstrings during a maximal isometric flexion movement in hemiparetic stroke patients. The effect of such a protocol on gait parameters and spasticity of the quadriceps will be evaluated also.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Stroke Spasticity, Muscle Muscle Fatigue Gait, Hemiplegic

Interventions

Muscle fatiguePROCEDURE

Isokinetic quadriceps muscle fatigue of the paretic lower limb

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age between 18 and 80y * Hemiparesis after a first-ever stroke \> 3 months * Spasticity of the quadriceps muscle * Quadriceps strength at least at 3/5 (MRC testing) * Subject able to walk at least 2min without rest * Informed consent * Social security affiliation Exclusion Criteria: * Severe comprehension troubles (language, cognitive or psychiatric disorders) * History of previous stroke, locomotor or other neurological disorders * Locomotor troubles affecting the paretic arm * Contraindication to efforts : cardiac insufficiency, severe aortic valvular stenosis, recent heart failure, non treated high blood pressure, severe peripheral arterial disease * Pregnancy or breastfeeding * Adult subject to guardianship

Locations (1)

Hôpital Swynghedauw, CHU

Lille, France

Outcomes

Primary Outcomes

Cocontraction Index (CCI) between the rectus femoris and the semitendinosus

ratio of the RMS of a the rectus femoris when acting as antagonist to the effort intended (knee flexion) to the RMS of the same muscle when acting as an agonist during a reciprocal maximal isometric knee flexion effort (500 ms around the peak of rectified EMG

Time frame: one day

Secondary Outcomes

Cocontraction Index (CCI) between the other parts of the quadriceps and the semitendinosus muscle

ratio of the RMS of a the vastus medialis, lateralis and intermedius when acting as antagonist to the effort intended (knee flexion) to the RMS of the same muscle when acting as an agonist during a reciprocal maximal isometric knee flexion effort (500 ms around the peak of rectified EMG

Time frame: one day

Agonist Recruitment Index of the semitendinosus

ratio of the RMS of a muscle acting as an agonist during a given period to its largest RMS value observed during the 500 ms around its agonist recruitment peak

Time frame: one day

Isometric peak knee flexion torque

Isometric peak knee flexion torque assessed by a CONTREX dynamometer

Time frame: one day

Spasticity of the quadriceps

Tardieu scale angle

Time frame: one day

spatio-temporal gait parameters at comfortable speed

Gait speed

Time frame: one day

spatio-temporal gait parameters at comfortable speed

Gait cadence

Data from ClinicalTrials.gov

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