There is not yet a standardized system of human embryonic culture in vitro. In addition, technical improvements continually appear. The investigators recently carried out a study in which it shows that the grouped embryo culture at low oxygen tension (5% O2) in a benchtop incubator shows better success rates than individual culture at atmospheric oxygen tension (20% O2) in a conventional incubator. For these reasons, the investigators have decided to continue this research line to evaluate the efficacy of a new ART station with a closed environment in comparison of an open flow cabinet. This new system keeps a controled environment maintaining a carbon dioxide (CO2) concentration of 6% and a temperature of 37 degrees. A prospective randomized study will be carried out in which the manipulation of the gametes and pre-embryos of the patients will be carried out in open laminar flow cabinets or in a closed station that maintain the CO2 and temperature conditions.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
78
Embryo handling is performed inside a closed station with a controlled environment: 6% CO2 and 37 degrees.
IVI Sevilla
Seville, Spain
Embryo quality
Rate of viable embryos = Transferred and Frozen embryos / Total number of embryos obtained
Time frame: Through study completion, an average of two years
Live birth rate per first embryo transfer
Total number of live births over the total of recruited patients (taking into account only the first cycle)
Time frame: Through study completion, an average of two years
Cumulative live birth rate
Total number of live births over the total of recruited patients (taking into account fresh and cryopreserved cycles)
Time frame: Through study completion, an average of two years
Implantation rate
Total of implanted embryos / total of transferred embryos
Time frame: Through study completion, an average of two years
Live birth rate of the first cycle per transferred embryo
Total number of live births over the total of transferred embryo
Time frame: Through study completion, an average of two years
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