Study of the Reversibility of Vigilance Dysfunction at 6 Months of Continuous Positive Airways Pressure (CPAP) in Patients With Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS)

Poitiers University Hospital23 enrolled

Overview

It is a monocentric prospective pilot study in Poitiers University Hospital, specifically analyzing the vigilance disorders in the Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) and their reversibility after 6 months of Continuous positive airways pressure (CPAP). All subjects were administered a test of vigilance (Test of Attentional Performance) both before and after the 6 months of CPAP. The main objective is the study of the reversibility of alertness disorders on the number of omissions in the subtest visual vigilance of the TAP ( (Test of Attentional Performance) at 6 months of CPAP in the OSAHS in patients with a memory complaint.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Vigilance Dysfunction

Interventions

Eligibility

Sex: ALLMin age: 20 YearsMax age: 69 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged 20-70 years * Memory disorders without memory problems in episodic memory * Presence of polysomnography of a obstructive sleep apnea/hypopnea syndrome (OSAHS) requiring Continuous positive airways pressure * Moderate OSAHS (Apnea Hypopnea Index ≥ 15 / hour with arousals ≥ 10) * Severe OSAHS (Apnea Hypopnea Index ≥ 30 / h) Exclusion Criteria: * Age \<20 years or ≥ 70 years * Neurodegenerative disease (Alzheimer's disease, Parkinson's disease) * Dysthyroidism * Severe depression, schizophrenia, bipolar disorder * Treatment with an effect on cognition: hypnotics, sedative * Chronic Obstructive Pulmonary Disease * Chronic alcoholism, other addictions * Contraindications to Magnetic Resonance Imaging * Refusal of equipment

Outcomes

Primary Outcomes

Study of the reversibility of vigilance disorders on the number of omissions in the subtest visual vigilance of the TAP

Reversibility of vigilance disorders on the number of omissions in the subtest visual vigilance of the TAP

Time frame: After 6 months of continuous positive airways pressure in the OSAHS patient