Effect of Intraoperative IV Ketamine on Postoperative Morphine Consumption During Intestinal Surgery

Assiut University60 enrolled

Overview

.The aim of this study is to identify the analgesic effect of intraoperative ketamine intravenous infusion on patients undergoing intestinal surgery and its effect on salivary cortisol and alpha amylase levels as indicator of its effect.

I- Group K (ketamine): 30 patients will receive intraoperative intravenous ketamine infusion. II- Group C (control): 30 patients will receive intraoperative intravenous normal saline infusion.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Postoperative Analgesia

Interventions

Ketamine HydrochlorideDRUG

intravenous ketamine infusion intraoperatively

Normal salineDRUG

intravenous normal saline infusion intraoperatively

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * \- Patient's status ASA status-I and II. * Patients age above 18 years old. * Patients scheduled for intestinal surgery. Exclusion Criteria: * Patient refusal. * Patients with known allergy to ketamine or morphine. * Patients with significant hepatic dysfunction. * Patients with severe renal disease. * Significant Heart disease. * Patients with chronic pain. * Regular use analgesics, antidepressants or opioids in last 2 months. * Any known convulsive disorder. * Morbid obesity (BMI\>35). * Patients with autoimmune disease * Patients on corticosteroid therapy * Pregnancy. * Breast feeding. * Woman under hormonal treatment. * Oral disease.

Outcomes

Primary Outcomes

morphine consumption

IV PCA

Time frame: 2 days postoperative

Secondary Outcomes

cortisol level

salivary

Time frame: 2 days postoperative

alpha amylase level

salivary

Time frame: 2 days postoperative

Central Contacts

mohamed aly, MD

CONTACT

00201062011126 galalm1967@yahoo.com

Data from ClinicalTrials.gov

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