Evaluating Iron Protein Succinylate Oral Solution in Treating Chronic Heart Failure and Iron Deficiency

Inclusion Criteria: 1. Sign informed consent form; 2. Between 18 to 80 years old, male or female; 3. Patients with chronic ejection fraction reduction heart failure, has been accepted the medication recommended by the Guidelines for treatment of heart failure in China (2014) for at least 4 weeks (that comply with the following requirements): if there is no contraindications or intolerance, patients should receive the renin angiotensin aldosterone system inhibitors, B blockers, and no dose adjustment within 4 weeks (not including diuretics). For patients who do not follow the guidelines for the use and titration of the renin angiotensin aldosterone system inhibitor and B blocker drugs, the cause should be recorded; 4. LVEF\< 40% (determined by Simpson method) (valid for one week before randomization); 5. NYHA heart function II-III Grade; 6. NT-proBNP\>400pg/ml, it should be .900pg/ml at atrial fibrillation; 7. Upper limit of hemoglobin: women less than 120g/L, men less than 130g/L. Lower limit of hemoglobin: more than 90g/L for both men and women. Accompanied by Iron deficiency (iron deficiency is defined as serum ferritin\<100ug/L, or serum ferritin between 100\~300ug/L with transferrin saturation (Tsat) \<20%); 8. Capable of 6 Minute walk test. Exclusion Criteria: 1. Patients with significant bleeding: gastrointestinal bleeding, menorrhagia, history of gastrointestinal bleeding and no evidence of gastrointestinal disease healing; 2. History of oral iron supplementation and intolerance; 3. History of acquired iron overload; 4. Exclude if receiving erythropoietin, intravenous iron, transfusion therapy and oral iron (including iron contained in compound vitamins or other compound medicine) ≧75mg/day within 6 weeks before enrollment; 5. Patients in urgent need of blood transfusion; 6. VtaminB12 and/or folate deficiency, unless correctable; and Non-iron deficiency anemia; 7. Severe renal insufficiency（eGFR \< 20ml/min/1.73m2, MDRD formula）, renal anemia; or history of kidney dialysis, need of kidney dialysis at present or in 6 months; 8. Chronic liver disease, cirrhosis, active hepatitis, transaminases (increase of alanine aminotransferase and aspartate aminotransferase 3 times above the normal upper limit. Total bilirubin 3 times higher than the normal upper limit); 9. Intestinal diseases which affect iron absorption such as inflammatory bowel disease and chronic pancreatitis; 10. Active infection; 11. History of syncope within 3 months, diagnosed as cardiogenic shock over the past 1 months; 12. Active myocarditis, constrictive pericarditis and other pericardial diseases; 13. Acute decompensated heart failure with unstable hemodynamics; 14. Symptomatic bradycardia or second or third-degree cardiac conduction block with no pacemaker installed; 15. Severe chronic obstructive pulmonary disease, pulmonary heart disease, severe pulmonary vascular disease, pulmonary hypertension caused by autoimmune diseases and any type of severe pulmonary hypertension; 16. Valvular heart disease and congenital heart disease without operation; hypertrophic cardiomyopathy, restricted cardiomyopathy, and other secondary cardiomyopathy; 17. Patients with malignancy; 18. Patients combined with other organ diseases such as hematopoietic system, nervous system, endocrine system like thyroid, and combined with psychosis; 19. There is uncontrolled hypertension, systolic pressure is greater than 180mmHg and/or diastolic pressure is greater than 110mmHg; 20. Heart rate ≥ 130 times/minute before randomization, or malignant ventricular arrhythmia affecting hemodynamic; 21. Neuromuscular disease, disability or other non-cardiac causes influencing the performance of 6 Minute walk test; 22. Occurred within 3 months: acute coronary syndrome, stroke, transient cerebral ischemic attack; cardiac, carotid artery or other major vascular surgery; percutaneous coronary intervention (PCI) or carotid artery angioplasty or coronary bypass surgery and other cardiac surgery; or scheduled for percutaneous intervention and surgery surgical treatment within 6 months; 23. Has been implanted pacemaker/defibrillator (CRT-P/D) of cardiac resynchronization therapy within 6 months, or the intention to implant a similar device within 6 months after randomization; 24. Has been received major surgery within 6 months prior to randomization, or intend to receive major surgical treatment within 6 months; 25. History of heart transplantation or waiting for transplantation or using a left ventricular assist device (LVAD) or a heart transplant intention (waiting for transplantation) or intend to use VAD over the next 6 months; 26. Nursing or pregnant women, or women of childbearing age without contraception, or patients planned pregnancy in 6 months; 27. History of major organ transplant (such as lung, liver, bone marrow, kidney) 28. Patients have been involved or to be involved in other clinical trials within one month; 29. Patients cannot understand the informed consent form or cannot make decisions or of poor compliance; 30. Patients judged as unsuitable for the study and life expectancy less than 1 year by investigators.