miRNA Profile in Aneurysmal Subarachnoid Haemorrhage

Chinese University of Hong Kong100 enrolled

Overview

The investigators aim to investigate and understand the circulating miRNA profiles after acute aneurysmal subarachnoid haemorrhage and underlying pathological significance.

1. The investigators aim to investigate the miRNA classifier for delayed cerebral infarction after aneurysmal subarachnoid haemorrhage; 2. The investigators aim to investigate the corresponding circulating and CSF miRNA profiles.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Subarachnoid Hemorrhage

Eligibility

Sex: ALLMin age: 21 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Aneurysmal subarachnoid hemorrhage patients within the first 72 hours or Healthy volunteers Exclusion Criteria: Previous neurological diseases such as stroke or dementia

Locations (1)

Department of Surgery, The Chinese University of Hong Kong

Hong Kong, China

Outcomes

Primary Outcomes

Circulating micro RNA concentrations

Serum micro RNA concentrations

Time frame: Day 3

Secondary Outcomes

Circulating micro RNA change

Changes of serum micro RNA concentrations between days 1,2,3,7

Time frame: Days 1,2,3,7

Cerebrospinal fluid micro RNA concentrations

Time frame: Day 1,2,3,7

Cerebrospinal fluid micro RNA change

Changes of cerebrospinal fluid micro RNA concentrations between days 1,2,3,7

Time frame: Days 1,2,3,7

Data from ClinicalTrials.gov

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