Asherman's syndrome is characterized by the presence of intrauterine adhesions (IUA) as well as symptoms such as amenorrhea, hypomenorrhea, pelvic pain, and infertility. The gold standard for the treatment of intrauterine adhesions is hysteroscopic intrauterine adhesions. The recurrence of intrauterine adhesions is a major challenge in clinical practice. It has been reported that dried biological aminion graft was used to prevent adhesion after the operation of intrauterine adhesions. Estrogen is also used for postoperative prevention of intrauterine adhesions. Intrauterine balloon can reduce the recurrence of adhesions after operation. Does the combination of balloon with amniotic products or estrogen can improve clinical outcomes? Therefore, this study was conducted.
Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Double (participant and outcomes Assessor) Primary Purpose: Prevention
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
100
The disposable balloon uterine stent is heart-shaped that resembled the shape of the uterine cavity and could fully separate the two sides of the uterine wall and the corners of the uterus compare to Foley catheter.
Uterine application of amnion membrane following hysteroscopic adhesiolysis. Other Name: Human amnion membrane
oral estradiol valerate tablets+dydrogesterone tablets
Beijing Obstetrics and Gynecology Hospital,Capital Medical University
Beijing, Beijing Municipality, China
RECRUITINGIncidence of adhesion information
Intrauterine adhesions under hysteroscopy
Time frame: Within the first 3 months after surgery
Menstruation pattern
menstrual volume which was assessed by pictorial blood loss assessment chart
Time frame: Within the first 3 months after surgery
The change of AFS score
The American Fertility Society ( AFS ) scoring system (1988 version). Scores of 1-4, 5-8, and 9-12 were mild, moderate, and severe adhesions, respectively.
Time frame: Within the first 3 months after surgery
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