Study of Immune Responses to Influenza Vaccination

University of Pennsylvania150 enrolled

Overview

Better understanding of the immune responses to influenza vaccination is needed in order to understand situations of poor vaccine response. Adults will receive influenza vaccination and then have peripheral blood drawn at pre-defined intervals in order to study the lymphocyte responses.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

150

Conditions

Influenza Vaccination

Interventions

Influenza vaccinationBIOLOGICAL

Adults will receive one intramuscular dose of seasonal quadrivalent inactivated influenza vaccine, as indicated for standard of care.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Community-dwelling adults able to provide consent who need influenza vaccination for standard of care Exclusion Criteria: * febrile illness at time of vaccination * active malignancy * use of immunosuppressing medications * blood donation in the past 60 days * influenza vaccinated during the preceding 6 months * allergic reactions to influenza vaccination

Locations (1)

University of Pennsylvania

Philadelphia, Pennsylvania, United States

Outcomes

Primary Outcomes

Influenza neutralizing antibody titers

Time frame: 21-42 days

Data from ClinicalTrials.gov

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