Outcomes of Adipose Derived Mesenchymal Stem Cells on Sexual Hormone Deficiency

Inclusion Criteria: * Age: 35 years to 70 years (Male) and from 35 years to menopause age (Female) * Male: decrease in libido, decrease in intercourse frequency, erectile dysfunction, Difficulty in concentration, testosterone level ≤ 12 nMol/dL * Female: reduced or absent menstruation after radiation exposure or chemotherapy; Hot flushes, excessive sweating, and anxiety, together with other symptoms associated with the menopause, AMH level ≤ 2 ng/ml and/or FSH level ≥ 10 mIU/ml. * Patients signed the informed consent form Exclusion Criteria: * Surgery removal of endocrine glands * Abnormalities in the endrocrine glands * Hormone deficiency due to diabetes and other metabolic disorders * Active autoimmune diseases * Current usage of immunosuppressive drugs * Coagulation disorders * Allergy to anesthetic agents * Severe health conditions such as cancer, failure of heart, lung, liver or kidney * Active infections