Pilot Study Comparing Ventilation Modes During CPR With Mechanical Compression Device.

Technical University of Munich30 enrolled

Overview

Comparison of three ventilation modes (volume controlled, BIPAP and CPAP) during cardiopulmonary re-suscitation with a mechanical compression device in the emergency room. Primary aim is to assess mean ventilation volume in the first 15 minutes after randomization.

Mechanical compression devices are applied to grant continuous chest compressions and consequently blood flow during CPR (cardiopulmonary rescuscitation). Current guidelines, however, are lacking guidance of the optimal ventilation strategy in such scenarios. This may lead to lung injuries caused by high pressure levels in the chest while applying compression and ventilation simultaneously or hypoventilation. Consequently, this pilot study assesses iwhich ventilation mode is optimal. Patients will be assigned randomly to one of the three ventilation modes (Volume controlled, BiPAP-ASB, CPAP). Ventilation parameters will be continuously monitored for 15 minutes while blood gas analyses are taken as well. Further secondary outcome parameters will be assessed, e.g. hospital mortality.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Cardiopulmonary Resuscitation

Interventions

Volume controlled ventilationPROCEDURE

Volume controlled ventilation mode

Pressure controlled ventilationPROCEDURE

Pressure controlled ventilation

CPAP modePROCEDURE

CPAP mode only

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * On-going out of hospital CPR in the Emergency Room * Tracheal intubated * Use of mechanical chest compression device Exclusion Criteria: * If the treating team assumes that CPR will be ceased within the next 15 minutes

Locations (1)

Klinikum rechts der Isar

Munich, Bavaria, Germany

Outcomes

Primary Outcomes

mean tidal volume

mean tidal volume during the study period

Time frame: Study period = 15 min (Startpoint = Activating randomized ventilation mode Endpoint = 15 minutes after Starting point or end of CPR)

Secondary Outcomes

mean minute volume

mean minute volume during the study period

Time frame: Study period = 15 min (Startpoint = Activating randomized ventilation mode Endpoint = 15 minutes after Starting point or end of CPR)

etCO2

Mean, final value and course of the parameter during the study period

Time frame: Study period = 15 min (Startpoint = Activating randomized ventilation mode Endpoint = 15 minutes after Starting point or end of CPR)

Data from ClinicalTrials.gov

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