The main purpose of this study is to define the molecular profile of selected solid tumors. From each participants will be collected biological materials for molecular analysis, including saliva, blood and vital tumor tissue derived form surgical or biopsy procedures. Whereas possible, vital tumor specimens will be inoculated and propagated in immunocompromised NOD/SCID mice to study the genetic correlations between genetic status and response to target drugs.
Study Type
OBSERVATIONAL
Enrollment
2,500
Ospedale Regionale Umberto Parini
Aosta, Italy
Policlinico S.Orsola Malpighi
Bologna, Italy
Istituto Di Candiolo - Fondazione Del Piemonte Per L'Oncologia (FPO-Irccs)
number of patient correctly sampled
number of patients with biological samples idoneous for molecular profiling testing (nucleic acid extraction, protein) over all recruited patients.
Time frame: through study completion, an average of five years
number of patients with detected genetic alterations that respond to treatments assigned by physician.
Time frame: through study completion, an average of five years
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Candiolo, Italy
Azienda Ospedaliero-Universitaria Careggi
Genova, Italy
Azienda Ospedaliera Niguarda Ca'Granda
Milan, Italy
IEO - Istiuto Europeo di Oncologia
Milan, Italy
Fondazione IRCCS - Istituto Nazionale dei Tumori
Milan, Italy
AOU S. Luigi Gonzaga
Orbassano, Italy
IOV - Istituto Oncologico Veneto
Padova, Italy
Azienda Ospedaliero Universitaria Pisana
Pisa, Italy
...and 5 more locations